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Researchers have taken a major step towards creating synthetic embryo-like structures that mimic real human embryos with most of the fundamental features of the earliest stages of life.
The latest study, from researchers at the Weizmann Institute in Israel, built on the work of a number of recent experiments using human embryonic stem cells and has created the most complete embryo produced so far.
“This is a landmark study that opens up new avenues for research into human development” said Prof Alfonso Martinez Arias at Pompeu Fabra University in Barcelona, Spain.
The aim of the research is not to create synthetic, or artificial life, but to produce working models that will allow scientists to study crucial stages in human development that are obscured from view as early-stage embryos develop inside the womb.
The research “is a step towards opening a window on the period of human development where many pregnancies fail and which has been really difficult to study up until now,” said Dr James Briscoe at the Francis Crick Institute in London.
The embryos that gave rise to all of us start with a sperm and an egg.
Here, the researchers use stem cells from donated human embryos which were then “coaxed” using chemical cues to develop into the four basic cell types of the early embryo that give rise to all the tissues and organs of a fully-formed human.
Previous experiments have produced similar embryos but ones that lack the same number of tissue types and levels of organisation found in real embryos.
Crucially, they lacked the “extraembryonic” tissues, like the cells that go on to form the placenta.
Read more:
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The placenta, and its implantation into the lining of the womb, is a leading cause of failure in pregnancy – and therefore an important area of research.
The synthetic embryos created by the…
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