NFL Week 6 game picks, schedule guide, fantasy football tips, odds, injuries and more

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6:45 AM ET

ESPN staff

The Week 6 NFL schedule for the 2021 season is stacked with great matchups, and we’ve got you covered with what you need to know heading into the weekend. Our NFL Nation reporters bring us the biggest keys to every game, a bold prediction for each matchup and, of course, final score picks.

Additionally, ESPN Stats & Information provides a big stat to know for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. ESPN researcher Kyle Soppe hands out helpful fantasy football and betting nuggets as well. Everything you want to know is here in one spot to help you get ready for a loaded weekend of NFL football.

Let’s get into the full Week 6 slate, including a big showdown between Lamar Jackson and Justin Herbert, another trip to London and a chess match between the Cowboys and Patriots. It all culminates with a Monday Night Football matchup between the Bills and the Titans on ESPN. (Game times are Sunday unless otherwise noted.)

Thursday: TB 28, PHI 22
Bye: ATL, NO, NYJ, SF

9:30 a.m. ET | CBS | London
Matchup rating: 13.6 | Spread: MIA -3 (47)

What to watch for: Dolphins QB Tua Tagovailoa is expected to return — and under must-win stakes. If the Dolphins don’t win at least two of their next three games, they’ll be left with a record only one other team in modern NFL history has ever come back from to make the playoffs. So the pressure is on the second-year quarterback to resuscitate a stagnant offense (31st in yards per game and 30th in passing yards per game) in London. — Marcel Louis-Jacques

Bold prediction: Jaguars QB Trevor Lawrence and Tagovailoa will each throw for more than 300 yards. Both teams’ pass defenses rank in the bottom quarter of the league. They have allowed a combined 19 touchdown passes, have intercepted just…

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Source : espn