NFL Week 10 game picks, schedule guide, fantasy football tips, odds, injuries and more

The Week 10 NFL schedule for the 2021 season is stacked with great matchups, and we’ve got you covered with what you need to know heading into the weekend. Our NFL Nation reporters bring us the biggest keys to every game, a bold prediction for each matchup and, of course, final score picks.

Additionally, ESPN Stats & Information provides a big stat to know and a betting nugget for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. ESPN researcher Kyle Soppe hands out helpful fantasy football tips as well. Everything you want to know is here in one spot to help you get ready for a loaded weekend of NFL football.

Let’s get into the full Week 10 slate, including a red-hot Titans defense facing Alvin Kamara and the Saints, Chase Young chasing after Tom Brady, the potential returns of Russell Wilson and Aaron Rodgers and a big AFC West matchup between the Chiefs and Raiders on Sunday night. It all culminates with a Monday Night Football matchup between the Rams and the 49ers on ESPN. (Game times are Sunday unless otherwise noted.)

Jump to a matchup:
CLE-NE | NO-TEN | TB-WSH
BUF-NYJ | ATL-DAL | JAX-IND
DET-PIT | MIN-LAC | CAR-ARI
SEA-GB | PHI-DEN | KC-LV
LAR-SF

Thursday: MIA 22, BAL 10
Bye: CHI, CIN, NYG, HOU

1 p.m. ET | CBS
Matchup rating: 67.5 | Spread: NE -2.5 (45)

What to watch for: The Patriots have relied on the run game in recent weeks, averaging 137.4 yards over their past five games and helping take some pressure off rookie quarterback Mac Jones. But running on the Browns might be their greatest challenge, as the Cleveland defense allows the NFL’s third-fewest rushing yards (84.8) and second-fewest yards per rush (3.5). So it might come down to Jones’ ability to throw it in the critical situations. — Mike Reiss

Bold prediction: One week after Cleveland cornerback Denzel Ward’s 99-yard pick-six, the Browns will score another defensive touchdown. That…