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Liver tumors died off in a third of patients enrolled in a study who received immunotherapy treatment before surgery, according to Mount Sinai researchers in New York City. The study was recently published in The Lancet Gastroenterology & Hepatology.
Liver cancer is one of the deadliest and most common cancers, the study’s senior author and associate professor of medicine (hematology and medical oncology) at the Icahn School of Medicine at Mount Sinai, Dr. Thomas Marron, told Fox News in an interview.
A doctor shows the shape of a liver to a patient.
(iStock)
“While we can cure it sometimes with surgery, unfortunately it often comes back—more often than most other cancers—and so one of the main reasons we did this trial was to find a way to decrease the likelihood the cancer will come back,” Marron, who is also the director of the Early Phase Trials Unit at The Tisch Cancer Institute and holds a Ph.D. in Immunology, said in a release discussing the recent report.
WHY IT’S DIFFICULT TO DIAGNOSE LIVER CANCER
The researchers of the phase 2 trial found that immunotherapy given before surgery, known as neoadjuvant immunotherapy, may kill not only the tumor but also microscopic cancer cells that surgery may miss, according to the report. If missed, the cancer cells could cause cancer to metastasize or reoccur, Marron told Fox News and explained the immunotherapy treatment helped boost the immune system’s ability to fight off cancer recurrences.
The Mount Sinai researchers administered two rounds of the immunotherapy agent, cemiplimab, to 21 early-stage liver cancer patients three weeks prior to surgery. Marron told Fox News that cemiplimab is an anti–PD-1 antibody that targets the tumor’s defense system.
The medical oncologist explained that the tumor has a protein, called PDL1, that…
Source : foxnews
